There has been increasing international attention to the experiences of lesbian, gay, bisexual, and transgender (LGBT) students in schools, and a growing concern regarding anti-LGBT violence and bias directed at youth as a serious human rights issue and barrier to global development goals. This special issue highlights research that has been done with and/or by nongovernmental organizations and provides a global perspective on the experiences of LGBT students. These articles provide insight into school climate for LGBT students in different country contexts but also on the efficacy of interventions on behalf of these youth (e.g., anti-bullying policies, educator professional development, awareness campaigns). Furthermore, this special issue demonstrates the multiple roles that research has played within advocacy communities working to create safer and more affirming school experiences for LGBT youth.