The use of antipsychotic medications within the school-age population is rapidly increasing. Although typical antipsychotics may be used in rare cases, this influx is largely secondary to the availability of the atypical antipsychotics. Reduction of possible adverse effects and increased efficacy represent the primary basis for the atypical antipsychotics' popularity over traditional agents. Although these agents, as their name suggests, are most commonly used to alleviate positive, as well as some negative, symptoms of psychotic manifestations, empirical evidence has suggested their efficacy in the treatment of other presentations. These include bipolar disorder, Attention-Deficit/Hyperactivity Disorder and other disruptive behavior disorders, pervasive developmental disorders, anorexia nervosa, and tic disorders. Discussion of antipsychotic agents and their use in these presentations is offered. Information on positive and negative outcomes, including school impact, is provided.