In this article we draw parallels between defined critical features of response-to-intervention (RTI) and the mastery learning approach described in the general education literature by Benjamin S. Bloom. We posit that these two processes include many common elements but that each incorporates unique elements that could potentially complement and strengthen the other. Finally, we outline the specific advantages a synthesis of these two processes offer both special educators and general educators in their efforts to enhance the effectiveness of instructional programs for all students.