An experiment for the undergraduate organic chemistry laboratory is described in which students synthesize the commercial antidepressant drug moclobemide, marketed under the trade name Manerix. This one-step synthesis starts from commercially available material and produces moclobemide in high yield. The product is initially isolated as its hydrochloride salt via precipitation. After recrystallization and treatment with base moclobemide is isolated in pure form. The purity and identity of the product are confirmed by melting point and NMR and IR spectroscopy. (Contains 2 figures and 2 schemes.)