A culturally grounded group intervention for a typically underserved population of urban American Indian women is described. The intervention is designed to increase interpersonal connection, improve inter-tribal acceptance and trust, and enhance psychological well being of marginalized urban American Indian women. Topics used to structure the intervention were generated collaboratively with tribal community members and included self-exploration and education, aging, body image, work, friendship, love commitment, and nurturance/motherhood. For illustrative purposes, the authors elaborate on two of these group therapy topics and provide member and leader reflections.