In this article, Judith V. Boettcher provides ten core learning principles that can guide technology-enhanced teaching as well as more traditional forms of instruction. Drawn from both traditional pedagogical theory as well as current research about how people learn, the ten principles integrate these findings in a helpful set of guidelines that give emphasis to issues of instructional design. Boettcher first presents a fourfold framework that delineates the respective roles of the learner, the faculty-mentor, the knowledge and content of instruction, and the environment in which learning occurs. Subsequent principles then provide more focused treatment of these four elements while highlighting further pedagogical concepts that should inform course design, teaching practice, and assessment measures. In discussing these principles, Boettcher suggests ways in which online technology can help educators create learning environments that respect the individual needs of students, foster collaboration, and promote deeper, sustained levels of engagement with the course content. (Contains 1 figure.)