This study examines whether perceived parent support, peer support, and the interaction between them predict depression symptoms and depression diagnosis 2 years later in a community sample of 389 adolescents. Controlling for Time 1 depression, parent support and anticipated peer support were not independently related to Time 2 depression in either linear or logistic regression analyses. However, there was a significant interaction between the two support variables, suggesting that parent support moderates the relationship between anticipated peer support and depression symptoms and diagnosis. Anticipated peer support is protective among adolescents with high parental support, but may act as a risk factor for adolescents with low parental support. Regarding developmental differences, low anticipated peer support at Time 1 was a stronger predictor of Time 2 depression symptoms among older, compared with younger, adolescents. These findings highlight the importance of parent and peer support in predicting future depression among community adolescents.