The purpose of this study was to determine the relationship between various coping-related variables and the evaluation of self-worth and subjective well-being among persons with spinal cord injury. Positive coping variables included hope, proactive coping style, and sense of humor, whereas negative coping variables included perceptions of stress, dysfunctional attitudes, and catastrophizing. Evaluations of self-worth were determined by measures of self-esteem and acceptance of disability. Quality of life and life satisfaction were indicators of subjective well-being. The results of the study indicate that negative coping has a negative association with both positive self-worth and subjective well-being. Feelings of positive self-worth were found to be positively associated with subjective well-being. In addition, positive coping appears to influence subjective well-being positively by first increasing feelings of positive self-worth. The findings indicate that coping strategies play an important role in the psychosocial adjustment of individuals with disabilities, and subsequently, in their quality of life. The implications for counseling individuals with disabilities are discussed. (Contains 1 table and 2 figures.)