College students have long been considered a population particularly affected by sleep difficulties. Previous studies have confirmed individuals with sleep disturbances may be at risk for development of depression. This study provides evidence in support of the hypothesis that sleep and specific aspects of depression are related. 147 students completed a demographic questionnaire, the Beck Depression Inventory-II (BDI-II), and a modified version of the Pittsburgh Sleep Quality Index (PSQI). 115 of these students participated in a second phase of the study, completing the National Sleep Foundation's Sleep Diary for two weeks and a second BDI-II. Results showed 43.5% of the sample reported having experienced depression for more than two weeks at some point in their lifetime and approximately 38% consistently reported trouble going to sleep or remaining asleep. Gender differences in depression correlated with the BDI sleep variable; when this item was removed from analysis, no gender differences in depression remained. The study identifies specific symptoms of depression most strongly related to sleep disturbances. The results of this study have important real-world implications for both prevention and treatment of depression in college students. (Contains 3 tables.)