Prior studies have examined stress, life satisfaction, and emotional intelligence in college students. Research on stress in college students has focused on the sources of stress, coping styles, and relevant outcomes. Research on life satisfaction has focused on specific relationships between life satisfaction and concepts like worry, self-concepts, and life events. Further, some studies have examined the relationships between stress and life satisfaction, emotional intelligence and stress, as well as emotional intelligence and life satisfaction. The present study examined three main hypotheses: 1) stress is negatively correlated with life satisfaction in college students; 2) emotional intelligence is positively correlated with life satisfaction; and 3) the interaction between stress and emotional intelligence affects life satisfaction. The first two hypotheses focused on replicating and further supporting findings from the research literature. The third hypothesis examined whether emotional intelligence moderated the effect of stress on life satisfaction, which has been unexplored thus far in the research literature. Support was found for the first hypothesis, but not for the second and third. Implications of the results are discussed, as well as directions for future research.