The present study investigated the relationship between stress and substance use among 347 Asian American, 346 Latino, and 776 White college students. Although stress was not found to predict substance use among the ethnic/ethnic group studied, results of the study indicated that Latino students reported a significantly higher stress level than White students. The overall findings augment the paucity of previous research about race and ethnicity in relation to substance use. With increasing Asian American and Latino students on college campuses, more attention must be given to issues that may impede their retention and graduation.