Objective: Using a stress carry-over perspective, this study examines the relationship between stress stemming from school and family domains and physical and mental health outcomes. Methods: The study sample included 268 undergraduate men and women from a Midwestern university. Participants completed an anonymous online questionnaire. OLS regression was used to analyze stress and health outcomes. Separate equations were estimated for men and women. Results: Men and women report higher school than family stress spillover, and women report higher school stress spillover than men. Regression models show that both men and women report more days of poor mental health when school spillover is high. Sleep hours are negatively associated with school spillover for women, and with family spillover for men. Conclusions: It appears that the carry-over of stress operates both similarly and differently for college men and women, affecting at least one physical health outcome and perceived mental health. (Contains 2 tables.)