Family-related stressors pose special challenges for adolescents of Mexican origin, given traditional cultural norms that compel youths to get involved with family problems despite their limited ability to effect change. The current study examines the prospective effects of coping strategies (i.e., active, distraction, avoidance, support-seeking, and religious coping) on psychological symptoms in the context of family stress with a sample (N = 189) of Mexican Origin adolescents (11-14). Hypotheses on the limits of coping were partially supported. Stress-coping interaction effects were further moderated by gender. Stress-buffering effect of active coping for internalizing symptoms was only found for girls and only at low levels of family stress for boys. Support-seeking and distraction coping both increased internalizing symptoms for boys at high levels of family stress. (Contains 2 tables and 2 figures.)