Major worldwide trends point to increased global interdependency and interrelatedness, to a growing need to overcome barriers that separate cultures, and to the development of new leadership that is culturally fluent and aware of cross-cultural opportunities and problems. This paper addresses major global-related questions and trends and the development of a "cultural mind" that considers differing values and assumptions, time orientations, ways of thinking, and decision-making styles. The role of the Project for Intercultural Development in helping to overcome these differences and ethnocentrism is discussed, and the dimensions of culturally fluent leadership are highlighted in terms of: (1) self-understanding; (2) knowledge of other cultures; (3) beliefs in the roles of synergy and change; (4) perspective and vision; (5) communication and empathy; (6) technical and professional skills; (7) process skills; and (8) leadership abilities. The current state in the development of culturally fluent leaders is explored in terms of schools, universities, corporations, communities, specific programs, and planning for the future. Three figures and 31 references are included. (JHP)