A novel stereochemistry lesson was prepared that incorporated both handheld molecular models and embedded virtual three-dimensional (3D) images. The images are fully interactive and eye-catching for the students; methods for preparing 3D molecular images in Adobe Acrobat are included. The lesson was designed and implemented to showcase the 3D virtual images and determine whether the use of virtual 3D images should be permanently included with the stereochemistry lesson. A group of students completed the lesson and provided positive feedback on the incorporation of the embedded virtual 3D images. (Contains 3 tables, 2 figures, and 3 notes.)