This article examines the effect of frequency and type of Internet use on perceived social support and sense of well-being in persons with spinal cord injury. The results show that Internet use is not significantly related to perceived social support. Bivariate analysis indicates that there is a significant negative association between total Internet use and overall sense of well-being. Simultaneous regression further investigated the nature of this relationship by examining the contribution of 10 online activities to four scales measuring sense of well-being. Frequency of online gaming was negatively associated with each scale. Disability-related information seeking was also negatively associated with psychological and financial well-being, as well as perceived social support. These results suggest that Internet use as a whole should not be overlooked by rehabilitation counselors for its practical uses to increase independence and social connectedness in persons with disabilities; however, care should be used, particularly with online gaming.