The aim of the study is to investigate the applicability of structured interviews for exploration of quality-of-life goals using an established instrument. Structured interviews were performed using WHOQOL-BREF and Disabilities Module as guideline with 35 clients admitted for first rehabilitation intervention after spinal cord injury. Although participants found some questions difficult to answer or psychologically stressful, most of them have appreciated the interviews' help considering their position in life at an early phase of rehabilitation. WHOQOL-BREF and Disabilities Module is an appropriate tool as an interview guideline for exploring quality-of-life goals.