This paper provides a descriptive narrative on some recent research processes and outcomes in general classrooms in Australia that include students with multiple and severe disability. A mentor-model approach to professional development for the teaching staff was employed and this paper outlines what happened, along with some of the specific needs and goals of the participating students and teaching personnel. Although the results were quite variable, a number of interesting findings relating to teacher effects and the limited role of peers in enhancing interactions with students with such complex needs are identified and discussed.