There is no doubt that soybean is the most important crop for Argentina, with a planted surface that rose 11,000,000 hectares and a production of around 35,000,000 metric tons. During the 1990s, there was a significant agriculture transformation in the country, motorize by the adoption of transgenic crops (soy-bean, maize, and cotton) under the no-tillage system. The expansion of this model has been spread not only in the Pampas but also in very rich areas with high biodiversity, opening a new agricultural border to important eco-regions like the Yungas, Great Chaco, and the Mesopotamian Forest. Transgenic cropping is a powerful technology. This produced relevant transformations over the environment and society where it is allowed. Migration, concentration of agribusiness, and loss of food sovereignty are some of the social results. Landscape transformation in the rural sector is evident, and the appearance of tolerance weeds to glyphosate is a reality. Nutrient depletion, soil-structure degradation, potential desertification, and loss of species are other consequences on the environmental level.