In this research our purpose was to examine the effectiveness of a program in retaining women in science, mathematics, and engineering majors. We compared undergraduate women participating in a support and mentoring program with nonprogram students in terms of their retention in these majors. The pretest and posttest results over one academic year revealed that the program was successful, adding to the call for support programs or orientation courses directed toward women. The findings had implications for many young men, as well. (Contains 5 tables.)