This case study is centered upon the recent debate concerning the decision by Texas Governor Rick Perry to mandate the compulsory vaccination of girls in the Texas public school system against the human papillomavirus (HPV) prior to entering the sixth grade. The interrupted case method is particularly appropriate for this subject with the case sections providing a general overview of the disease, the reasons for such a mandatory vaccination program, the reasons against such a program, and finally a disclosure of what ultimately transpired in Texas.