It has been suggested that self-efficacy expectations may have a cognitive influence on career decision making (CDM) and vocational achievement (e.g., range of career options and persistence in career exploration). Personal self-efficacy expectations may influence the CDM process and career motivation. This study explored the role of self-efficacy and career decision making in students with physical disabilities engaged in the career planning process. The relationships of career decision-making self-efficacy to adjustment of disability, severity of disability, and career exploration behaviors were examined in 128 students with physical disabilities attending two 2-year colleges and one 4-year college in California. Findings revealed that, as predicted, students with physical disabilities who scored high on career decision-making self-efficacy engaged in more career exploration behaviors. As hypothesized, there was a positive correlation between adjustment to disability and career decision-making self-efficacy. Severity of disability was a significant predictor of levels of career decision-making self-efficacy and adjustment to disability. There was no significant difference in levels of career decision-making self-efficacy between students in 2-year colleges and those in 4-year college. Implications for career counseling practice and suggestions for future research are discussed. (GCP)