Preservice teachers' pedagogical content knowledge (PCK) development was investigated with respect to integrating technology. Four components of PCK were adapted to describe technology-enhanced PCK (TPCK). The study examined the TPCK of student teachers in a multi-dimensional science and mathematics teacher preparation program that integrated teaching and learning with technology throughout the program. Five cases described the difficulties and successes of student teachers teaching with technology in molding their TPCK. Student teachers view of the integration of technology and the nature of the discipline was identified as an important aspect of the development of TPCK.