This study examined the relationship of academic self-efficacy to engagement in class discussion and performance on major course exams among students (N = 165) in an undergraduate human development course. Cluster analysis was used to identify three levels of academic self-efficacy: high (n = 34), medium (n = 91), and low (n = 40). Results indicated that high, medium, and low academic self-efficacy all significantly predicted levels of student participation and exam performance, but the directionality of group placement on the academic measures was different for students at the high self-efficacy level versus those at the low and mid self-efficacy levels. Cluster analysis was also used to divide students into high, medium, and low grade-point average (GPA). These groups did not differ significantly on either self-efficacy or class participation but did differ on exam performance. Within GPA levels, self-efficacy was most strongly related to class participation and exam performance at the highest level of GPA and least related at the lowest level of GPA.