For science to be taught properly and effectively, labs must be an integral part of the science curriculum. The National Science Teachers Association (NSTA) recommends that all preK-16 teachers of science provide instruction with a priority on making observations and gathering evidence, much of which students experience in the lab or the field, to help students develop a deep understanding of the science content, as well as an understanding of the nature of science, the attitudes of science, and the skills of scientific reasoning (NRC 2006, p. 127). Furthermore, NSTA is committed to ensuring that all students--including students with academic, remedial, or physical needs; gifted and talented students; and English language learners--have the opportunity to participate in laboratory investigations in a safe environment. This paper presents NSTA's declarations on laboratory investigations in science instruction. (Contains 1 resource.)