Twenty-eight freshmen majoring in biology and/or chemistry in an Arab college in Israel, were given a pre-test and a post-test in which they had to identify the control group and design a controlled experiment. During the course an intervention was used. Science was taught by inquiry while using strategies that promote higher-order thinking skills like case studies and reading scientific research articles. The study found that learning methods had a significant effect on developing HOTS among the study participants. Also, the students expressed positive attitude, both emotionally and cognitive as a result of the intervention.