While comprehensive texts, articles, and literature reviews presenting research in the singular arenas of motivation, help-seeking, and online science learning are relatively easy to find, syntheses and interactions between these constructs are lacking. Part I of this review addresses this knowledge gap by drawing together key research from the domains of educational psychology and adult education, addressing the constructs of motivation, self-efficacy, adult learning, and help-seeking. Part II of this review extends and applies the motivation and help-seeking discussion to the emerging and exciting field of online chemistry education. The result is a comprehensive synthesis of the strengths and limitations of the currently existing body of knowledge related to the motivation and help-seeking behaviors of adult, online chemistry students.