The case study reported in this paper is part of a larger multiple cross case analysis focusing on pre-service teachers with various initial confidence and attitudes toward science and science teaching. In this paper, the focus will be on one elementary teacher candidate, Lisa, who began the science methods course with a negative attitude and low self-efficacy. An in-depth description of her beliefs, attitude, and self-efficacy, before and after the course, the impact of her prior science experience and the science methods course on shaping these domains, and the possible interrelationship between the three variables are discussed. The findings revealed the impact of Lisa's prior science experiences on all three domains and shed light on the interrelationship between her beliefs, attitude, and self-efficacy. Her course experiences allowed for changes in her beliefs about science and science teaching, and an improved attitude toward and a stronger sense of confidence toward learning and teaching science.