The study of anatomy is a content-dense discipline with a challenging vocabulary. A mnemonic is a series of letters, a word, a phrase, or a rhyme that students can use when studying to facilitate recall. This project was designed to promote active learning in undergraduate students studying anatomy and physiology by asking them to create limericks based on course content and then to evaluate the limericks written by their peers for learning value, accuracy, style, and adherence to limerick characteristics. Students (278 and 288, respectively, in the 2009 and 2010 sections of ANP1107) worked in groups of three to create a total of 242 limericks. Peer evaluation was accomplished in two stages using a 20-point marking rubric. In Stage 1, students were randomly divided into 10 groups (n = 23 [plus or minus] 2 students) with each group member evaluating the same 12 [plus or minus] 1 limericks. In Stage 2, the top 19% of limericks were reevaluated by all students so that the best three could be chosen. In each of the two years, 60% of students completed all parts of the assignment. Higher percentages (75-80%) participated in limerick writing and one of the two assessment stages. A positive association was noted between level of student participation in the limerick assignment and final course marks. Limerick creation and evaluation can be used to promote active learning by encouraging students to review functional-anatomy-based content to create limericks with good learning value and to provide valid assessments of limericks written by their peers.