In this paper, we examine the effects of computer-assisted instruction (CAI) on adult at-risk learners in fundamental mathematics education. This examination includes comparing the results of adult learners experiencing learning with CAI with those who do not. Further, we explore and present viable teaching and learning strategies for at-risk students with a focus on a Web-based approach. Both qualitative and quantitative methods are applied to explore the effect of CAI on adult at-risk learners. The analysis of the data suggests not only a positive effect of CAI on student learning of mathematics, but also concerns and issues arising from the learning experience. (Contains 7 tables.)