This article provides an introduction to the TLRP Learning How to Learn Project and a context for the articles that follow in this special issue. The origins of the research, in a concern to investigate the organizational and network conditions that support innovation in teaching and learning, and in a perceived need to align research on pedagogy and assessment with research on school improvement, are described. Details of the overall development and research design are given as well as an explanation of the ways in which different forms of quantitative and qualitative data analysis are being integrated to interrogate a "logic model", both at whole sample level and in case studies. (Contains 2 figures, 1 table, and 8 endnotes.)