Pascarella (J Coll Stud Dev 47:508-520, 2006) has called for an increase in use of longitudinal data with pretest-posttest design when studying effects on college students. However, such designs that use multiple measures to document change are vulnerable to an important threat to internal validity, regression to the mean. Herein, we discuss a brief history of regression to the mean and illustrate a straightforward procedure to make adjustments to initial pretest scores for regression to the mean effects utilizing a method developed by Roberts (in: G. Echternacht (Guest ed.) New directions for testing and measurement, 1980). Analyses are shown with both unadjusted and adjusted pretest scores, illustrating dramatic differences in conclusions about whether students change across time.