This handbook has been developed as a resource to be used by peer/community educators and mobilisers conducting HIV/AIDS prevention programmes in the informal sector workplaces and surrounding communities in Uganda. The handbook provides basic information on a range of topics on HIV and other sexually transmitted infections that can be used by community educators and mobilisers when facilitating discussions, group meetings and workshops on HIV/AIDS issues among informal sector workers. The information in this handbook is presented in topics/modules that can be easily used either as stand-alone for short group meetings/discussions or as part of a larger training programme. It is recommended that educators and mobilisers that have had orientation training on HIV/AIDS use this handbook.