This doctoral thesis contributes to the literature on self-efficacy and self-esteem and the relationship to a student's school, age, gender, ethnicity, GPA, paid and introductory pharmacy practice experiences in a Doctor of Pharmacy (PharmD) program. Graduates with a high level of self-efficacy and self-esteem are more desirable as pharmacists upon graduation. A quantitative survey, which includes two standardized instruments, the Generalized Self-Efficacy Scale (GSE) and the Rosenberg Self-Esteem Scale (RSES), was administered to students at five schools of pharmacy in the northeast United States, resulting in a total of 399 responses. The findings confirm the significance of paid experiences and increased levels of a student's self-efficacy in a pharmacy setting. The other finding was related to ethnicity where the Asian/Pacific Islander students showed lower self-efficacy than other ethnic groups, which may be due to a cultural difference in displaying traits of high self-efficacy. Self-esteem also showed a positive finding for students with paid experiences and students who were older. There was an ethnicity finding where Asian/Pacific Islanders scored lower on the self-esteem scale, while the African-Americans scored higher than all the other groups. The results show that students improve their levels of self-efficacy and self-esteem through extended practical experiences. Schools should provide structured experiences of a sufficient length, beyond the present 300 hours, to prepare students for their transition into a professional role. Educators should be aware of the difference in Asian/Pacific Islander culture and encourage students to demonstrate their self-efficacy and self-esteem so other professionals can recognize them for their attributes. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]