"Science Briefs" summarize the findings and implications of a recent study in basic science or clinical research. This brief reports on the study "Evidence for a Gene-Environment Interaction in Predicting Behavioral Inhibition in Middle Childhood" (N. A. Fox, K E. Nichols, H. A. Henderson, K. Rubin, L. Schmidt, D. Hamer, M. Ernst, and D. S. Pine). In a study of children observed as babies and again at school age, it was found that children were more likely to become anxious and shy individuals if they had a genetic predisposition to anxiety and their mothers lacked social support, resulting in environmental stress for the children. [Study Title and Authors: Fox, N. A., Nichols, K. E., Henderson, H. A., Rubin, K., Schmidt, L., Hamer, D., Ernst, M., & Pine, D. S. (2005). Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. "Psychological Science" 16: 921-926.]