This volume is a report of a workshop held in 2003 to address best practices and remaining challenges with respect to national laboratory-university collaborations. The following are appended: (1) Committee Member Biographies; (2) Workshop Agenda; (3) Workshop Participants; (4) Glossary of Acronyms; and (5) Major Benefits and Challenges. [This study was also supported by Lawrence Berkeley National Laboratory; Lawrence Livermore National Laboratory; Los Alamos National Laboratory; Pacific Northwest National Laboratory; Sandia National Laboratories; and the University of California, Berkeley.]