Although there is evidence that literacy deficiencies in adolescents can be remedied with one-to-one tutoring using research-based instructional strategies, a review of current literature provides only limited information on transferring effective instructional strategies to learning environments outside of one-to-one tutoring centers. The authors of this article identify three components of successful one-to-one literacy tutoring programs, discuss what research reveals regarding one-to-one literacy instruction with adolescents, and provide commentary on how the instruction used in their reading clinic can be replicated for those attempting to apply one-to-one literacy instruction inside a tutoring center, resource room, or traditional classroom setting. (Contains 1 table.)