The goal of the present work was to examine the effects of bilingualism on adults' ability to resolve cross-linguistic inconsistencies in orthography-to-phonology mappings during novel-word learning. English monolinguals and English-Spanish bilinguals learned artificially constructed novel words that overlapped with English orthographically but diverged from English phonologically. Native-language orthographic information presented during learning interfered with encoding of novel words in monolinguals but not in bilinguals. In general, bilinguals outperformed monolinguals on the word-learning task. These findings indicate that knowledge of 2 languages facilitates word learning and shields English-Spanish bilinguals from interference associated with cross-linguistic inconsistencies in letter-to-phoneme mappings. (Contains 2 tables and 1 figure.)