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50 Years of ERIC
50 Years of ERIC
The Education Resources Information Center (ERIC) is celebrating its 50th Birthday! First opened on May 15th, 1964 ERIC continues the long tradition of ongoing innovation and enhancement.

Learn more about the history of ERIC here. PDF icon

Showing 1 to 15 of 19 results
Clinical Responses to Atomoxetine in Attention-Deficit/Hyperactivity Disorder: The Integrated Data Exploratory Analysis (IDEA) Study
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Newcorn, Jeffrey H.; Sutton, Virginia K.; Weiss, Margaret D.; Sumner, Calvin R. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Data from six randomized controlled trials in the U.S. reveal that 47 percent of patients aged six to 18 years showed a much improved clinical response to atomoxetine as a treatment for attention deficit hyperactivity disorder while 40 percent did not have a response. Augmenting or switching treatment in non-responders by week 4 is suggested.
Descriptors: Attention Deficit Hyperactivity Disorder, Drug Therapy, Patients, Children
Medication Adherence in the MTA: Saliva Methylphenidate Sample versus Parent Report and Mediating Effect of Concomitant Behavior Treatment
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Papadopulos, Elizabeth; Jensen, Peter S.; Chait, Alanna R.; Arnold, L. Eugene; Swanson, James M.; Greenhill, Laurence L.; Hechtman, Lily; Chuang, Shirley; Wells, Karen C.; Pelham, William; Cooper, Thomas; Elliott, Glenn; Newcorn, Jeffrey H. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Saliva methylphenidate samples from participants in the Multimodal Treatment Study of Children with Attention Deficit and Hyperactivity Disorder reveal that nearly half of them had some degree of nonadherence to treatment. This suggests that nearly half of the parent reports of medication use are inaccurate.
Descriptors: Drug Therapy, Attention Deficit Hyperactivity Disorder, Compliance (Psychology), Children
The MTA at 8 Years: Prospective Follow-Up of Children Treated for Combined-Type ADHD in a Multisite Study
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Molina, Brooke S. G.; Hinshaw, Stephen P.; Swanson, James W.; Arnold, L. Eugene; Vitiello, Benedetto; Jensen, Peter S.; Epstein, Jeffery N.; Hoza, Betsy; Hechtman, Lily; Abikoff, Howard B.; Elliott, Glen R.; Greenhill, Laurence L.; Newcorn, Jeffrey H.; Wells, Karen C.; Wigal, Timothy; Gibbons, Robert D.; Hur, Kwan; Houck, Patricia R. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Participants of the Multimodal Treatment Study of Children with Attention Deficit and Hyperactivity Disorder (ADHD) eight years earlier do not differ significantly in repeated measures or newly analyzed variables that include school grades and psychiatric hospitalization. The treatment of childhood ADHD does not predict functioning six to eight…
Descriptors: Attention Deficit Hyperactivity Disorder, Children, Hospitalized Children, Followup Studies
Characteristics of Placebo Responders in Pediatric Clinical Trials of Attention-Deficit/Hyperactivity Disorder
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Newcorn, Jeffrey H.; Sutton, Virginia K.; Zhang, Shuyu; Wilens, Timothy; Kratochvil, Christopher; Emslie, Graham J.; D'Souza, Deborah N.; Schuh, Leslie M.; Allen, Albert J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2009
Objective: Understanding placebo response is a prerequisite to improving clinical trial methodology. Data from placebo-controlled trials of atomoxetine in the treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD) were analyzed to identify demographic and clinical characteristics that might predict placebo…
Descriptors: Attention Deficit Hyperactivity Disorder, Stimulants, Rating Scales, Patients
Pharmacotherapy of Aggression in a 9-Year-Old with ADHD
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Findling, Robert L.; Newcorn, Jeffrey H.; Malone, Richard P.; Waheed, Ayesha; Prince, Jefferson B.; Kratochvil, Christopher J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
A 9-year-old boy presents for assessment and treatment of his reactive, impulsive aggressive behavior that has been present for approximately 2 years. Six months ago, his pediatrician started treatment with OROS methylphenidate (MPH), which was titrated to 36 mg/day. There was moderate improvement in symptoms of attention-deficit/hyperactivity…
Descriptors: Hyperactivity, Aggression, Attention Deficit Disorders, Drug Therapy
Effect of Two Different Methods of Initiating Atomoxetine on the Adverse Event Profile of Atomoxetine
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Greenhill, Laurence L.; Newcorn, Jeffrey H.; Gao, Haitao; Feldman, Peter D. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: To compare the effects of two different methods for initiating atomoxetine in terms of the incidence of early adverse events. Method: Data on atomoxetine treatment-emergent adverse events in youths, ages 6 to 18 years, were analyzed from five randomized, double-blind, placebo-controlled, acute-phase studies. Two studies involve…
Descriptors: Patients, Drug Therapy, Symptoms (Individual Disorders), Sleep
High-Dose Atomoxetine Treatment of ADHD in Youths with Limited Response to Standard Doses
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Kratochvil, Christopher J.; Michelson, David; Newcorn, Jeffrey H.; Weiss, Margaret D.; Busner, Joan; Moore, Rodney J.; Ruff, Dustin D.; Ramsey, Janet; Dickson, Ruth; Turgay, Atilla; Saylor, Keith E.; Luber, Stephen; Vaughan, Brigette; Allen, Albert J. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: To assess the utility and tolerability of higher than standard atomoxetine doses to treat attention-deficit/hyperactivity disorder (ADHD). Method: Two randomized, double-blind trials of atomoxetine nonresponders ages 6 to 16 years were conducted comparing continued treatment with same-dose atomoxetine to treatment using greater than…
Descriptors: Hyperactivity, Attention Deficit Disorders, Rating Scales, Patients
Childhood Abuse, Nonadherence, and Medical Outcome in Pediatric Liver Transplant Recipients
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Shemesh, Eyal; Annunziato, Rachel A.; Yehuda, Rachel; Shneider, Benjamin L.; Newcorn, Jeffrey H.; Hutson, Carolyn; Cohen, Judith A.; Briere, John; Gorman, Jack M.; Emre, Sukru – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: The study assessed the relationship between a history of child abuse, nonadherence to medications, and medical outcome in children who had a liver transplant. Method: Abuse history for children and adolescents ages 8 to 21 who underwent a liver transplantation at Mount Sinai Medical Center in New York was obtained in interviews in 2002.…
Descriptors: Child Abuse, At Risk Persons, Drug Therapy, Compliance (Psychology)
Secondary Evaluations of MTA 36-Month Outcomes: Propensity Score and Growth Mixture Model Analyses
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Swanson, James M.; Hinshaw, Stephen P.; Arnold, L. Eugene; Gibbons, Robert D.; Marcus, Sue; Hur, Kwan; Jensen, Peter S.; Vitiello, Benedetto; Abikoff, Howard B.: Greenhill, Laurence L.; Hechtman, Lily; Pelham, William E.; Wells, Karen C.; Conners, C. Keith; March, John S.; Elliott, Glen R.; Epstein, Jeffery N.; Hoagwood, Kimberly; Hoza, Betsy; Molina, Brooke S. G.; Newcorn, Jeffrey H.; Severe, Joanne B.; Wigal, Timothy – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: To evaluate two hypotheses: that self-selection bias contributed to lack of medication advantage at the 36-month assessment of the Multimodal Treatment Study of Children With ADHD (MTA) and that overall improvement over time obscured treatment effects in subgroups with different outcome trajectories. Method: Propensity score analyses,…
Descriptors: Attention Deficit Hyperactivity Disorder, Research Methodology, Evaluation Methods, Models
Effects of Stimulant Medication on Growth Rates across 3 Years in the MTA Follow-up
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Swanson, James M.; Elliott, Glen R.; Greenhill, Laurence L.; Wigal, Timothy; Arnold, L. Eugene; Vitiello, Benedetto; Hechtman, Lily; Epstein, Jeffery N.; Pelham, William E.; Abikoff, Howard B.; Newcorn, Jeffrey H.; Molina, Brooke S. G.; Hinshaw, Stephen P.; Wells, Karen C.; Hoza, Betsy; Jensen, Peter S.; Gibbons, Robert D.; Hur, Kwan; Stehli, Annamarie; Davies, Mark; March, John S.; Conners, C. Keith; Caron, Mark; Volkow, Nora D. – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: To evaluate the hypothesis of stimulant medication effect on physical growth in the follow-up phase of the Multimodal Treatment Study of Children With ADHD. Method: Naturalistic subgroups were established based on patterns of treatment with stimulant medication at baseline, 14-, 24-, and 36-month assessments: not medicated (n = 65),…
Descriptors: Attention Deficit Hyperactivity Disorder, Stimulants, Norms, Statistical Analysis
Delinquent Behavior and Emerging Substance Use in the MTA at 36 Months: Prevalence, Course, and Treatment Effects
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Molina, Brooke S. G.; Flory, Kate; Hinshaw, Stephen P.; Greiner, Andrew R.; Arnold, L. Eugene; Swanson, James M.; Hechtman, Lily; Jensen, Peter S.; Vitiello, Benedetto; Hoza, Betsy; Pelham, William E.; Elliott, Glen R.; Wells, Karen C.; Abikoff, Howard B.; Gibbons, Robert D.; Marcus, Sue; Conners, C. Keith; Epstein, Jeffery N.; Greenhill, Laurence L.; March, John S.; Newcorn, Jeffrey H.; Severe, Joanne B.; Wigal, Timothy – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: To compare delinquent behavior and early substance use between the children in the Multimodal Treatment Study of Children With ADHD (MTA; N = 487) and those in a local normative comparison group (n = 272) at 24 and 36 months postrandomization and to test whether these outcomes were predicted by the randomly assigned treatments and…
Descriptors: Attention Deficit Hyperactivity Disorder, Delinquency, Behavior Modification, Therapy
3-Year Follow-up of the NIMH MTA Study
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Jensen, Peter S.; Arnold, L. Eugene; Swanson, James M.; Vitiello, Benedetto; Abikoff, Howard B.; Greenhill, Laurence L.; Hechtman, Lily; Hinshaw, Stephen P.; Pelham, William E.; Wells, Karen C.; Conners, C. Keith; Elliott, Glen R.; Epstein, Jeffery N.; Hoza, Betsy; March, John S.; Molina, Brooke S. G.; Newcorn, Jeffrey H.; Severe, Joanne B.; Wigal, Timothy; Gibbons, Robert D.; Hur, Kwan – Journal of the American Academy of Child & Adolescent Psychiatry, 2007
Objective: In the intent-to-treat analysis of the Multimodal Treatment Study of Children With ADHD (MTA), the effects of medication management (MedMgt), behavior therapy (Beh), their combination (Comb), and usual community care (CC) differed at 14 and 24 months due to superiority of treatments that used the MTA medication algorithm (Comb+MedMgt)…
Descriptors: Attention Deficit Hyperactivity Disorder, Behavior Modification, Psychopathology, Therapy
Elevated Childhood Serotonergic Function Protects against Adolescent Aggression in Disruptive Boys
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Halperin, Jeffrey M.; Kalmar, Jessica H.; Schulz, Kurt P.; Marks, David J.; Sharma, Vanshdeep; Newcorn, Jeffrey H. – Journal of the American Academy of Child & Adolescent Psychiatry, 2006
Objective: This longitudinal study examined whether responsiveness of the neurotransmitter serotonin (5-HT) in childhood predicts adolescent aggression. Method: Boys (N = 33) with disruptive behavior disorders who received assessments of central 5-HT function via the prolactin response to fenfluramine between 1990 and 1994 when they were 7 to 11…
Descriptors: Aggression, Behavior Disorders, Children, Males
Do Children and Adolescents with ADHD Respond Differently to Atomoxetine?
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Wilens, Timothy E.; Kratochvil, Christopher; Newcorn, Jeffrey H.; Gao, Haitao – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: Controversy exists over changes in tolerability and response to medications across the life span. Here the authors report data contrasting the efficacy and tolerability of atomoxetine between children and adolescents with attention-deficit/hyperactivity disorder (ADHD). Method: Data were analyzed for children ages 6-11 (510 atomoxetine,…
Descriptors: Adolescents, Rating Scales, Hyperactivity, Attention Deficit Disorders
Family and Cognitive Factors: Modeling Risk for Aggression in Children with ADHD
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Miller, Carlin J.; Miller, Scott R.; Trampush, Joey; McKay, Kathleen E.; Newcorn, Jeffrey H.; Halperin, Jeffrey M. – Journal of the American Academy of Child and Adolescent Psychiatry, 2006
Objective: To explore the relationships of family and cognitive factors to aggression as reported by parents and teachers. Method: Data regarding different types of aggressive behavior were collected from parents and teachers of 165 school-age (7-11 years old) children referred to a study of attention-deficit/hyperactivity disorder and disruptive…
Descriptors: Structural Equation Models, Risk, Hyperactivity, Aggression
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