Research has shown consistently that first-generation college students are less prepared academically for college, have a higher risk for dropping out, and are less likely to obtain a degree. This study investigated the effect of first-generation students' participation in a first-year seminar (FYS) on academic achievement and persistence to the second semester compared to nonparticipants. The authors collected data from 266 first-generation students in an FYS and used a quasi-experimental design incorporating hierarchical propensity score matching techniques to form quasi-control groups. The results show the seminar had a significant positive effect on achievement (an overall GPA difference of 0.71 points) and persistence (an overall 17% difference).