The effects of three classes of reinforcing stimuli were compared across three students with profound intellectual disabilities. A multielement design with no baseline and final "best treatments" phase was used to measure the frequency of single-switch activations by each student across treatments. The three interventions were Treatment A, adapted toys and devices; Treatment B, cause-and-effect commercial software; and Treatment C, instructor-created video programs. Stimulus activations using a single switch were consistently greater when using individualized computer-based video programs. Implications for identifying stimuli for students who may not respond to traditional methods for teaching means-end contingencies (cause and effect) are discussed.