Collaboration plays a major role in interdisciplinary activities among Science, Technology, Engineering & Mathematics (STEM) disciplines or fields. It also affects the relationships among cluster members on the management team. Although effective collaboration does not guarantee success among STEM disciplines, its absence usually assures problems. More specifically, collaboration has the obvious roles of identifying talents coming together for a common purpose of combining knowledge and sharing responsibility, creativity, and experience of others. Facilitating collaboration across Science, Technology, Engineering, and Mathematics (STEM) fields in program development is critical to providing a strong educational foundation to all learners in STEM education. This synergistic effort among educators and other professionals across the STEM fields will enable effective knowledge sharing in program development. This paper addresses leadership and knowledge sharing among collaborators in STEM program development through facilitating collaboration across STEM fields.