The authors examined the associations between acculturation, supervisors' multicultural competence, and clinicians' self-efficacy in a sample of 153 immigrant therapists currently practicing in the United States. Participants completed a demographic questionnaire and 3 additional questionnaires that examined their levels of acculturation, perceived supervisors' multicultural competence, and clinical self-efficacy. Results suggested that perceived prejudice, not level of acculturation, was significantly associated with foreign-born therapists' clinical self-efficacy. Perceived supervisors' multicultural competence was significantly associated with therapists' clinical self-efficacy. Recommendations for supervisors working with foreign-born therapists are provided.