Purpose: The purpose of this paper is to describe the experiences of RCE Hamburg, one of the latest Regional Centres of Excellence (RCE) to be created. It outlines the activities performed by the RCE and describes its relationships with the various stakeholders. Design/methodology/approach: A description of the region where the RCE is located is provided, along with some facts and figures related to the site. In addition, a description of the structure and the activities of the RCE Hamburg is provided, complemented by a description of the engagement of various stakeholders. Findings: The paper shows that, by means of projects and action-based initiatives, synergies between regional centres of expertise on education for sustainable development and agencies based at the local level can be achieved. Originality/value: The RCE is characterised by an integrated approach where different target groups are involved (e.g. schools, NGOs and industry) and where a local university plays a catalyst role. (Contains 5 figures and 1 table.)