Human immunodeficiency virus (HIV) infection rates in the United States continue unabated among some groups, with young adults of color at greater risk than others. This study sought to determine college students' knowledge, perceptions, and behaviors related to HIV/AIDS. Undergraduate students (N = 443) at a large, urban Hispanic-serving institution in south Texas were surveyed. Participants' self-reported knowledge of HIV transmission was moderate; significant differences exist between age and ethnic groups for some items. Implications for education and prevention campaigns are discussed. (Contains 4 tables.)