Evidence-based approaches to the design of the next generation of interactive distance education need to take into account established multimedia learning principles. Cognitive load theory is a theory that has significantly contributed to the development of such principles. It has applied our knowledge of major features and processing limitations of human cognitive architecture to enhancing the effectiveness of instructional methods and techniques. The paper describes major assumptions and principles of cognitive load theory followed by its general recommendations for instructional methods and techniques, and then by implications for the design of interactive multimedia learning in distance education.