Higher education is rapidly expanding and diversifying across all regions of the globe. Much of that growth has been absorbed by the expansion of the private and for-profit sector, a trend that is particularly prevalent in Asia. Higher education is not only expanding but is also becoming increasingly global, with a mix of different corporate, academic, national and ethnic cultures influencing and becoming embedded within post-secondary institutions. Thus far, few studies have focused on developing nuanced descriptions of the organisational and cultural challenges involved in the development of new for-profit institutions within rapidly expanding higher education systems. This qualitative case study utilised individual and group interviews among members of the academic staff and administration to provide an in-depth look at a newly created for-profit institution of higher learning in the Philippines. Following a modified grounded theory analysis process, findings illustrate how different and sometimes conflicting layers of culture impact efforts to create a new for-profit higher education institution.