Introduction: This study aims to explore the consumption of alcohol and other drugs in university students and to verify whether there are gender differences in the consumption of these substances. Method: A descriptive study using self-reports. Drug consumption was evaluated in 506 students from the University of Almeria (60.9% women and 34.6% men). A self-report measure was created specifically for this investigation; it collects information about the intensity and frequency of alcohol and other drug use. Other instruments used were the "CAGE" (alcohol), the "AAS", the "APS", the "AUDIT" and the "MAC". Results: Results show that alcohol is the preferred substance, the most widely consumed, and the substance most often used by university students to achieve states of inebriation (about 70% of subjects). The second most consumed and preferred substance used by students for "getting high" is cannabis. If we analyze consumption in the past month, 82.6% of subjects have consumed alcohol, 32.6% cannabis and 3.0% designer drugs. In relation to gender, men consumed significantly more alcohol and cannabis than women, when analyzing the past week. Discussion and Conclusion: These results are similar to those obtained at other Spanish universities, but prevalence rates exceed those found in studies that examine a general, young population, or students between the ages of 14 and 18. (Contains 4 tables.)