Individuals with greater levels of purpose and meaning tend to be happier, demonstrate greater selfcontrol, strong values, and have healthier mental attitudes (Molasso, 2006a; Steger, 2009). It has been suggested that knowing one's talents may be related to the development of purpose, but this hypothesis has not been previously tested. This study examines the self-efficacy belief in one's talents identified through the Clifton StrengthsFinder® and its relationship to hope, well-being, and meaning in life among college students. Results from a path analysis indicate that these self-efficacy beliefs can predict hope and the presence of meaning in life, and the results may suggest that this inventory can be a practical assessment tool.