The Moffitt-Woodward-Moscowitz-Klyne-Djerassi octant rule is one of the most successful empirical rules in organic chemistry. However, the lack of a simple effective modeling method for the octant rule in the past 50 years has posed constant difficulties for researchers, teachers, and students, particularly the young generations, to learn and study this remarkable and powerful tool. A simple, effective, recordable, and universal computer-aided three-dimensional (CA3D) molecular modeling is presented for the octant rule, which is established by a combination of three common computer software programs in chemistry classrooms and laboratories. (Contains 1 figure.)